Infiltration of CD204-overexpressing Macrophages Contributes to the Progression of Stage II and III Colorectal Cancer

Background/Aim: M1 macrophages have antitumour effects, while M2 promote tumour proliferation and invasion. The clinical significance of the M2-specific marker CD204 has not been elucidated in colorectal cancer (CRC). We investigated prognostic CD204- CD68-positivity specimens from patients with CRC examined effects polarized-macrophages on proliferative invasive potentials cell lines vitro. Materials Methods: Surgical 206 Stage II III were by immunohistochemistry. Proliferation invasion assays flow cytometry used to investigate expression co-cultured three lines. Results: Infiltration CD204-positive cells was significantly associated shorter overall survival relapse-free survival; no association observed for CD68. M2-polarized promoted cells. Conclusion: Higher infiltration into tumour-microenvironment might be prognostically important CRC.